Mrs. Bezalel Ben Chaim LOEW, mother of the Maharal, was the daughter of Rabbi Chaim ISSEMHEIMER or the daughter of Rabbi Yitzchak KLOBER of Worms.
They had four sons and three daughters - Tha Maharal was their youngest son:
1. daughter Loew
2. Rabbi Chaim ben Bezalel LOEW (b. 1506? 1510? Worms, d. 1588, Rabbi of Freidberg).
3. Sinai LOEW (b. ca 1508 Worms, d. 1607 Kolin).
4. Rabbi Shimshon (Samson) ben Bezalel LOEW (b. 1522? 1510? Prague, d. Kremitz),
5. daughter married Zecharia Mendle KLOIZNER the Elder.
6. daughter married R. Avigdor KARA
7. The youngest son was the Maharal of Prague, Rabbi Judah (Yehuda) LOEW ben Bezalel (b. 1525 Posen or Pesach Eve. 1512 Worms, d. 22 August 1609 Prague, or 17 September 1609
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Rabbi Bezalel married the daughter of Rabbi Chaim ISSEMHEIMER or married daughter of Rabbi Yitzchak KLOBER of Worms.
1480
Loew [brother #4 of Maharal], Rabbi Shimshon (Samson) Ben BezalelLoew, Mrs. Zecharia MendelLoew [Maharal of Prague], R. Judah/Yehuda (ben Bezalel)Loew/Loeb, Rabbi Sinai ben BezalelLoew [Maharal brother #2], ABD Friedberg, Rabbi Chaim Ben BezalelLoew, Mrs. Rabbi AvigdorBat Betzalel ben Chaim, [Maharal's Sister #5) Loew, ???Loew [Maharal sister #1], Daughter of R.Bezalel